Molecular medicine in genetically engineered animals: series introduction.

January 1 Gene modification via “plug and socket” gene targeting.................................. Jada Lewis, Baoli Yang, ......................................................................................................................... Pete Detloff, and Oliver Smithies January 15 Biological insights through genomics: mouse to man ...................................... Edward M. Rubin and Gregory S. Barsh February 1 In vitro differentiation of murine embryonic stem cells: new approaches to old problems ..................................................................... Mitchell J. Weiss and Stuart H. Orkin February 15 Genes and physiology: molecular physiology in genetically engineered animals.......................................................................................... Kenneth R. Chien March 1 Animal models of human disease for gene therapy......................................... James M. Wilson March 15 New methods for genetic alteration and phenotypic analysis in the mouse .... Andras Nagy and Janet Rossant April 1 Transgenesis in the rat and larger mammals................................................... John Mullins and Linda Mullins April 15 Zebrafish as a model system to find genetic determinants of vertebrate physiology and disease .................................................................. Mark Fishman and Wolfgang Driever May 1 Recent advances in conditional gene mutation by site-directed recombination.............................................................................. Jamey Marth and Klaus Rajewsky If only anatomists were as familiar with the dissection of lower animals as with that of the human body, all these perplexing difficulties would, in my opinion, be cleared up. The situation is first of all clear enough in fishes where there is a single ventricle in the heart, and not lungs. The sac at the base of the heart, doubtless corresponding to the auricle, pushes blood into the heart, which plainly transmits it by a tube analogous to an artery. This may be confirmed by inspection, or section of the artery, the blood spurting with each beat of the heart. It is not hard to see the same thing in other animals with but a single ventricle, as toads, frogs, serpents, and lizards.